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Characterization of the responses of inferior colliculus neurons of the chicken to electrical stimulation of the cochlear nerve Neufeld, Peter Richard
Abstract
Responses of inferior colliculus neurons of the anaesthetized, cochlea-ectomized chicken to electrical stimulation of the cochlear nerves were recorded extracellularly. At least three physiologically distinct cell types were found in the central nucleus of the inferior colliculus. Type 1 fired randomly and with a high spontaneous rate, exhibiting a Poisson distribution in the spike interval histogram. Stimulation of either cochlear nerve produced an inhibition lasting 3 to 46 ms (mean of 16.7, n=16). Type 2 exhibited little or no spontaneous activity, and responded to a short stimulus with a single spike or burst of spikes (n=21). Type 3 exhibited regular, spontaneous firing with preferred intrinsic frequencies in the audio range (n=26), usually resulting in multimodal spike interval histograms. Single pulse stimulation of the contralateral nerve reset the firing rhythm, resulting in periodic post-stimulus time histograms (PSTH). The intermodal interval for a PSTH of a type 3 cell was identical to the intermodal interval for a spontaneous interval histogram. A reverse correlation of a random sequence of stimulus pulses with the response spikes revealed preferred frequencies in the input which were similar to the output frequencies seen in post-stimulus time and interval histograms. Thus, these type 3 neurons exhibited both an oscillatory spontaneous and evoked firing pattern, and an intrinsic frequency selectivity which is presumed to give rise to the observed oscillation. These cells were found to be grouped together in a relatively small portion of the inferior colliculus. The location of several type 3 cells was identified using WGA-HRP injected from the recording electrode. These cells were found to be in the core of the central nucleus of the inferior colliculus. These findings suggest the existence of an intrinsic mechanism for frequency filtering and time coding in the CNS.
Item Metadata
Title |
Characterization of the responses of inferior colliculus neurons of the chicken to electrical stimulation of the cochlear nerve
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Creator | |
Publisher |
University of British Columbia
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Date Issued |
1994
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Description |
Responses of inferior colliculus neurons of the anaesthetized, cochlea-ectomized
chicken to electrical stimulation of the cochlear nerves were recorded extracellularly. At least
three physiologically distinct cell types were found in the central nucleus of the inferior
colliculus. Type 1 fired randomly and with a high spontaneous rate, exhibiting a Poisson
distribution in the spike interval histogram. Stimulation of either cochlear nerve produced an
inhibition lasting 3 to 46 ms (mean of 16.7, n=16). Type 2 exhibited little or no spontaneous
activity, and responded to a short stimulus with a single spike or burst of spikes (n=21). Type 3
exhibited regular, spontaneous firing with preferred intrinsic frequencies in the audio range
(n=26), usually resulting in multimodal spike interval histograms. Single pulse stimulation of
the contralateral nerve reset the firing rhythm, resulting in periodic post-stimulus time
histograms (PSTH). The intermodal interval for a PSTH of a type 3 cell was identical to the
intermodal interval for a spontaneous interval histogram. A reverse correlation of a random
sequence of stimulus pulses with the response spikes revealed preferred frequencies in the input
which were similar to the output frequencies seen in post-stimulus time and interval histograms.
Thus, these type 3 neurons exhibited both an oscillatory spontaneous and evoked firing pattern,
and an intrinsic frequency selectivity which is presumed to give rise to the observed oscillation.
These cells were found to be grouped together in a relatively small portion of the inferior
colliculus. The location of several type 3 cells was identified using WGA-HRP injected from
the recording electrode. These cells were found to be in the core of the central nucleus of the
inferior colliculus.
These findings suggest the existence of an intrinsic mechanism for frequency filtering
and time coding in the CNS.
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Extent |
1536394 bytes
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Genre | |
Type | |
File Format |
application/pdf
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Language |
eng
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Date Available |
2009-03-06
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Provider |
Vancouver : University of British Columbia Library
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Rights |
For non-commercial purposes only, such as research, private study and education. Additional conditions apply, see Terms of Use https://open.library.ubc.ca/terms_of_use.
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DOI |
10.14288/1.0087586
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URI | |
Degree | |
Program | |
Affiliation | |
Degree Grantor |
University of British Columbia
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Graduation Date |
1994-11
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Campus | |
Scholarly Level |
Graduate
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Aggregated Source Repository |
DSpace
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Item Media
Item Citations and Data
Rights
For non-commercial purposes only, such as research, private study and education. Additional conditions apply, see Terms of Use https://open.library.ubc.ca/terms_of_use.